Danofloxacin is a synthetic fluoroquinolone with broad spectrum antimicrobial activity.
Each 1 ml contains:
Danofloxacin mesilate: 31.722 mg (eq. to danofloxacin 25 mg)
Mode of action:
The antimicrobial activity of danofloxacin is based upon the inhibition of microbial DNA gyrase. Danofloxacin, in common with other quinolones, produces a stable complex between the enzyme and DNA. This results in the cessation of DNA replication and transcription, an effect which is the basis of the antimicrobial effect.
DANOCIN has bactericidal action against an ample range of gram-positive, gram-negative bacteria and mycoplasma.
DANOCIN has fast absorption in the injection site, reach levels of concentration after two hours of the initial treatment, suggesting extensive distribution to the indicated site of infection.
Indications: Danocin is indicated:
The Treatment of respiratory disease caused by Pasteurella Haemolytica, Pasteurella multocida and the treatment of enteric infections caused by Escherichia coli, Salmonella spp. in cattle.
The treatment of the respiratory diseases caused by: Pasteurella multocidaActinobacillus pleuropneumoniae and the treatment of enteric infection caused by E. coli in pigs.
Dosage and administration:
1. 1 ml/20 kg B.Wt. by I.M.I. or I.V.I.
2. 1 ml/4 kg B.Wt. by S.C.I as a single dose; repeated after 48 hours if required.
1 ml/20 kg B.Wt. by I.M.I. for 3 days
- Hypersensitivity to quinolones; pregnant cattle.
- Transient inflammatory reactions at site of injection.
- Nasal and ocular erythema
- Reduce food intake.
Cautions in animals with joint disease or cartilage growth disorders
Meat: 5 days
Milk: 48 hours.
Pigs: Meat: 3 days
Store below 25º C away form direct sun light and Keep out of the reach of children.
Packing: 25 ml, 50 ml, 100 ml & 250 ml vials + label & insert in carton box.